Drugs That Can Induce DRESS
The exact incidence of DRESS is unknown, but estimated to vary from one case among 1,000 to 10,000 drug exposures. DRESS may occur from an interplay of several factors: a) drugs b) viral reactivation (mostly HHV-6) c) immune disfunction d) a genetic predisposition. Some populations and ethnic groups have genetic factors that are identified with certain drugs and susceptibility (i.e. Allopurinol and Han Chinese HLA-B*58:01).
While over 50 drugs have been identified to cause DRESS, the most frequently reported are antiepileptics (carbamazepine, lamotrigine, phenytoin, allopurinol), and antibiotics (sulfonamides; vancomycin, minocyline, trimethoprim/sulfamethoxazole, sulfasalazine, dapsone).
Here you will find a list of DRESS causing drug along with their intended use and any known genetic risk factors. This list is not comprehensive but will be updated as more cases are reported and new gene/drug associations are identified .